Recent Publications

2019

Innate Immune Signaling Contributes to Tubular Cell Senescence in the Glis2 Knockout Mouse Model of Nephronophthisis. Jin H, Zhang Y, Liu D, Wang SS, Ding Q, Rastogi P, Purvis M, Wang A, Elhadi S, Ren C, Cao C, Chai Y, Igarashi P, Jetten AM, Lu D, Attanasio M. Am J Pathol. 2020 Jan;190(1):176-189. doi: 10.1016/j.ajpath.2019.09.013. Epub 2019 Oct 3. PMID: 31676329

Epithelial innate immunity mediates tubular cell senescence after kidney injury. Jin H, Zhang Y, Ding Q, Wang SS, Rastogi P, Dai DF, Lu D, Purvis M, Cao C, Wang A, Liu D, Ren C, Elhadi S, Hu MC, Chai Y, Zepeda-Orozco D, Campisi J, Attanasio M. JCI Insight. 2019 Jan 24;4(2). pii: 125490. doi: 10.1172/jci.insight.125490. PMID: 30674725

Persistent increase in mitochondrial superoxide mediates cisplatin-induced chronic kidney disease. Mapuskar KA, Wen H, Holanda DG, Rastogi P, Steinbach E, Han R, Coleman MC, Attanasio M, Riley DP, Spitz DR, Allen BG, Zepeda-Orozco D. Redox Biol. 2019 Jan;20:98-106. doi: 10.1016/j.redox.2018.09.020. Epub 2018 Sep 27. PMID: 30296702

Prominin-1 controls stem cell activation by orchestrating ciliary dynamics. Singer D, Thamm K, Zhuang H, Karbanová J, Gao Y, Walker JV, Jin H, Wu X, Coveney CR, Marangoni P, Lu D, Grayson PRC, Gulsen T, Liu KJ, Ardu S, Wann AK, Luo S, Zambon AC, Jetten AM, Tredwin C, Klein OD, Attanasio M, Carmeliet P, Huttner WB, Corbeil D, Hu B. EMBO J. 2019 Jan 15;38(2). pii: e99845. doi: 10.15252/embj.201899845. Epub 2018 Dec 6. PMID: 30523147

2016

Loss of Glis2/NPHP7 causes kidney epithelial cell senescence and suppresses cyst growth in the Kif3a mouse model of cystic kidney disease. Lu D, Rauhauser A, Li B, Ren C, McEnery K, Zhu J, Chaki M, Vadnagara K, Elhadi S, Jetten AM, Igarashi P, Attanasio M. Kidney Int. 2016 Jun;89(6):1307-23. doi: 10.1016/j.kint.2016.03.006. PMID: 27181777

Loss of diacylglycerol kinase epsilon in mice causes endothelial distress and impairs glomerular Cox-2 and PGE2 production. Zhu J, Chaki M, Lu D, Ren C, Wang SS, Rauhauser A, Li B, Zimmerman S, Jun B, Du Y, Vadnagara K, Wang H, Elhadi S, Quigg RJ, Topham MK, Mohan C, Ozaltin F, Zhou XJ, Marciano DK, Bazan NG, Attanasio M. Am J Physiol Renal Physiol. 2016 May 1;310(9):F895-908. doi: 10.1152/ajprenal.00431.2015. Epub 2016 Feb 17. PMID: 26887830

2015

Transcription Factor Hepatocyte Nuclear Factor-1β (HNF-1β) Regulates MicroRNA-200 Expression through a Long Noncoding RNA. Hajarnis SS, Patel V, Aboudehen K, Attanasio M, Cobo-Stark P, Pontoglio M, Igarashi P. J Biol Chem. 2015 Oct 9;290(41):24793-805. doi: 10.1074/jbc.M115.670646. Epub 2015 Aug 19. PMID: 26292219  

Hedgehog signaling indirectly affects tubular cell survival after obstructive kidney injury. Rauhauser AA, Ren C, Lu D, Li B, Zhu J, McEnery K, Vadnagara K, Zepeda-Orozco D, Zhou XJ, Lin F, Jetten AM, Attanasio M. Am J Physiol Renal Physiol. 2015 Nov 1;309(9):F770-8. doi: 10.1152/ajprenal.00232.2015. Epub 2015 Aug 19. PMID: 26290370

Ciliopathies and DNA damage: an emerging nexus. Attanasio M. Curr Opin Nephrol Hypertens. 2015 Jul;24(4):366-70. doi: 10.1097/MNH.0000000000000134. Review. PMID: 26050124

2014

Mutations in ANKS6 cause a nephronophthisis-like phenotype with ESRD. Taskiran EZ, Korkmaz E, Gucer S, Kosukcu C, Kaymaz F, Koyunlar C, Bryda EC, Chaki M, Lu D, Vadnagara K, Candan C, Topaloglu R, Schaefer F, Attanasio M, Bergmann C, Ozaltin F. J Am Soc Nephrol. 2014 Aug;25(8):1653-61. doi: 10.1681/ASN.2013060646. Epub 2014 Mar 7. PMID: 24610927

Whole-exome resequencing distinguishes cystic kidney diseases from phenocopies in renal ciliopathies. Gee HY, Otto EA, Hurd TW, Ashraf S, Chaki M, Cluckey A, Vega-Warner V, Saisawat P, Diaz KA, Fang H, Kohl S, Allen SJ, Airik R, Zhou W, Ramaswami G, Janssen S, Fu C, Innis JL, Weber S, Vester U, Davis EE, Katsanis N, Fathy HM, Jeck N, Klaus G, Nayir A, Rahim KA, Al Attrach I, Al Hassoun I, Ozturk S, Drozdz D, Helmchen U, O'Toole JF, Attanasio M, Lewis RA, Nürnberg G, Nürnberg P, Washburn J, MacDonald J, Innis JW, Levy S, Hildebrandt F. Kidney Int. 2014 Apr;85(4):880-7. doi: 10.1038/ki.2013.450. Epub 2013 Nov 20. PMID: 24257694

2011

Increased hedgehog signaling in postnatal kidney results in aberrant activation of nephron developmental programs. Li B, Rauhauser AA, Dai J, Sakthivel R, Igarashi P, Jetten AM, Attanasio M. Hum Mol Genet. 2011 Nov 1;20(21):4155-66. doi: 10.1093/hmg/ddr339. Epub 2011 Aug 4. PMID: 21816948

The genetic components of idiopathic nephrolithiasis. Attanasio M. Pediatr Nephrol. 2011 Mar;26(3):337-46. doi: 10.1007/s00467-010-1562-6. Epub 2010 Jun 19. Review. PMID: 20563734